He created his laboratory at the Centre d’Immunologie de Marseille-Luminy (CIML, CNRS, France), where he focuses on the cell biology of dendritic cell activation with projects studying proteolysis, membrane trafficking, stress pathways, and microbial detection. He is CNRS director of research since 2006 and was director of CIML from 2018-2023. Many of his discoveries have direct clinical applications in the treatment of cancer and inflammatory diseases, while his keen interest in protein aggregation and tRNA modifications has allowed him to be recruited as a team leader at the institute of BioMedecine (IBIMED) and adjunct professor at the University of Aveiro in 2014, through the support of an Ilidio Pinho Chair of molecular immunology.